Human papillomaviruses (HPVs) are highly prevalent and potent human pathogens that cause over 5% of all human cancers, including cervical cancer and a subset of head and neck cancers. HPV-associated cancers result in half a million deaths every year worldwide.

Our laboratory investigates the molecular mechanisms by which HPV drives cancer development and evades the host immune system, with a primary focus on Head and Neck Squamous Cell Carcinoma (HNSCC). By integrating functional genomics, single-cell analysis, human patient samples, and animal models, we aim to identify novel therapeutic targets that can reverse immune evasion and improve the effectiveness of current immunotherapies.